Erythritol and Brain Health: A New Study Raises Questions About This Popular Sugar Substitute
At BioChecked, we’re dedicated to keeping you informed about the latest developments in health and nutrition, especially regarding the ingredients in your food. A recent study published in the Journal of Applied Physiology (Berry et al., 2025) has raised concerns about erythritol, a widely used sugar substitute in sugar-free, low-carb, and keto-friendly products. While the findings are preliminary and more research is needed, they suggest potential risks worth considering. Here’s what you need to know to make informed choices.
What Is Erythritol?
Erythritol is a sugar alcohol used as a low-calorie sweetener in products like:
- Sweeteners: Truvia (blended with stevia), Swerve, Lakanto (often with monk fruit), NOW Foods Erythritol, Anthony’s Erythritol, and others.
- Keto and Low-Carb Foods: Keto ice creams (e.g., Halo Top, Rebel, Enlightened), cookies, protein bars, and “zero sugar” baked goods.
- Sugar-Free Candies and Gums: Chewing gums, mints, and hard candies.
- Beverages: Sugar-free sodas, flavored waters, teas, and coffees.
- Other Products: Sugar-free yogurts, fruit spreads, and small amounts in fermented foods like soy sauce.
Valued for its zero-calorie profile and tooth-friendly properties, erythritol is FDA-approved as generally recognized as safe (GRAS). However, new research prompts a closer look at its safety.
The New Study: Potential Concerns for Brain Health
Published on July 18, 2025, and reported by SciTechDaily, the study examined erythritol’s effects on human brain endothelial cells, which line blood vessels in the brain. The findings suggest that even moderate amounts (equivalent to one serving) may:
- Increase brain blood vessel constriction, potentially reducing clot-clearing ability.
- Boost free radical production, stressing brain tissue.
- Cause vascular changes that could elevate stroke risk.
These results build on prior studies linking erythritol to cardiovascular concerns. However, this research was conducted on cells in a lab, not humans, so its real-world implications remain unclear. More studies are needed to confirm these effects.
A Cautious Approach
BioChecked urges readers to approach these findings with cautious awareness. While erythritol is widely used and FDA-approved, this study highlights the need to stay informed about processed ingredients. When we move away from natural sweeteners like honey or fruit, we should expect potential consequences. Highly processed sugar substitutes, even those labeled “natural,” undergo significant processing that may impact the body in unexpected ways. This study reminds us to prioritize whole, minimally processed foods.
What Can You Do?
If you’re concerned about erythritol, consider these steps:
- Check Labels: Look for “erythritol” or “sugar alcohol” in ingredient lists, as it may not always be highlighted on nutrition labels.
- Explore Alternatives: Opt for less-processed sweeteners:
- Pure Stevia: SweetLeaf Stevia Drops or NOW Foods Pure Stevia (no sugar alcohols).
- Monk Fruit: Monk Fruit in the Raw or pure monk fruit extracts (avoid erythritol blends).
- Allulose: Wholesome Allulose or RxSugar.
- Choose Whole Foods: Use natural sweeteners like raw honey, maple syrup, or fruit in moderation.
- Limit Processed “Keto” Products: Many keto snacks rely on erythritol. Try ChocZero (select monk fruit-only products) or Nick’s Ice Cream (some stevia/allulose flavors).
- Stay Informed: Follow updates on erythritol research to understand its evolving safety profile.
The Bigger Picture
This study underscores a key principle: moving away from natural, whole foods can introduce unforeseen health risks. While erythritol helps reduce sugar and calories, its processing and widespread use may carry trade-offs we’re only beginning to understand. BioChecked advocates for transparency in food choices and encourages weighing the benefits and risks of processed ingredients.
Final Thoughts
The erythritol study is a call for vigilance, not panic. More research is needed to clarify its real-world impact. For now, read labels carefully, explore natural or less-processed sweeteners, and prioritize whole foods. Visit BioChecked for more resources to support your health journey.
Scott Prentice is the Executive Director and Founder of BioChecked™ and encourages everyone to stay proactive with their health and the food the consume.
